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Myo-Inositol:Pathway to Preventing Lung Cancer

Myo-inositol is a naturally occurring substance, along with the presence of the PI3K gene may be the "pathway" to preventing lung cancer. In a breakthrough study, researchers found that after taking the readily available dietary supplement, a gene identified as PI3K gets deactivated and slows lesion growth within those afflicted with one of the deadliest forms of cancer.

Doctors and researchers could predict which smokers will be afflicted with lung cancer with the detection of the PI3K gene. A clinical trial involving 60 patients through a combined effort of Andrea Bild from the University of Utah, Avrum Spira of Boston University, and Allegro Diagnostics made the discovery. The team collected samples from nonsmokers and smokers and found, as Bild stated a "certain pathway, PI3K, was turned on in patients that had lung cancer as opposed to patients that had other problems." The team also reported that the group of PI3K genes became tremendously active in lung cancer patients. The findings of Bild, Spira, and colleagues were published in the Science Translational Medicine journal.

The gene affects lesion growth, known as dysplasia, within healthy and unhealthy lung tissue. Researchers found that myo-inositol halted the growth of lesions in patients identified with the PI3K gene. Myo-inositol is available in dietary supplements and found in food like fruits, beans, nuts, and grains.

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